Increase Risk
-overweight
-have type 2 diabeties (increased liver uptake of fat)-Systemic carnitine deficiency
-have high blood pressure-high cholesterol
-experienced extreme weight loss
Treatment
-Liver Transplantation, when NAFLD progresses to liver failure
-No standard treatment exists.
-Weight loss, when have elevated blood lipids/obese
-Control blood sugar, diabetic
Prevention
-Healthy diet
-Heathy weight
Mitochondrial abnormalities are closely related to NAFLD
NAFLD may be a mitochondrial disease
Abnormalities include:
-ultra structural lesions
-depletion of mitochondrial DNA (mtDNA)
-decreased activity of respiratory chain complexes
-impaired mitochondrial β-oxidation
During NAFLD, the , mitochondria is big and swelled, scarce in number and the matrix has para crystalline inclusions and hypo density.
Patients treated with a drug(4,4'-diethylaminoethoxyhexestrol) that inhibits
mitochondrial respiratory chain (MRC) activity & mitochondrial β-oxidation, show
the same mitochondrial lesions.
NAFLD is often found in patients with insulin resistance, obesity and type 2
diabetes, decresed O2 consumption and ATP production, decresed total mtDNA and
mtDNA transcription factor A and reduced content of respiratory proteins in the
fat, muscle and liver.
mtDNA depletion in hepatocytes (liver tissue) impairs mitochondrial function
causing hepatic steatosis and other liver injury.
-overweight
-have type 2 diabeties (increased liver uptake of fat)-Systemic carnitine deficiency
-have high blood pressure-high cholesterol
-experienced extreme weight loss
Treatment
-Liver Transplantation, when NAFLD progresses to liver failure
-No standard treatment exists.
-Weight loss, when have elevated blood lipids/obese
-Control blood sugar, diabetic
Prevention
-Healthy diet
-Heathy weight
Mitochondrial abnormalities are closely related to NAFLD
NAFLD may be a mitochondrial disease
Abnormalities include:
-ultra structural lesions
-depletion of mitochondrial DNA (mtDNA)
-decreased activity of respiratory chain complexes
-impaired mitochondrial β-oxidation
During NAFLD, the , mitochondria is big and swelled, scarce in number and the matrix has para crystalline inclusions and hypo density.
Patients treated with a drug(4,4'-diethylaminoethoxyhexestrol) that inhibits
mitochondrial respiratory chain (MRC) activity & mitochondrial β-oxidation, show
the same mitochondrial lesions.
NAFLD is often found in patients with insulin resistance, obesity and type 2
diabetes, decresed O2 consumption and ATP production, decresed total mtDNA and
mtDNA transcription factor A and reduced content of respiratory proteins in the
fat, muscle and liver.
mtDNA depletion in hepatocytes (liver tissue) impairs mitochondrial function
causing hepatic steatosis and other liver injury.
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