1- "Nutrient excess leads to mitochondrial dysfunction, which in turn leads to obesity related pathologies."
2- Insulin resistance is a key indicator of type 2 diabetes. Which is linked to obesity whereby there is reduction in efficiency of glucose and fatty acid metabolism,and decreased glycogen synthesis. Recent studies are focused on the link between mitochodrial dysfunction and insulin resistance
1. Abstract from NCBI/Last Accessed 12/01/2013, 9.29pm/ Website : http://www.ncbi.nlm.nih.gov/pubmed/20585248
2. Information from: Mitochondrial Dysfunction in Type 2 Diabetes and Obesity by Kurt Højlund, MD, PhD et al./ Last Accessed 12/01/2013, 9.29pm/ Website : http://www.sciencedirect.com/science/article/pii/S0889852908000340
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