From an scientific article dated in 2009 - Mitochondrial diseases are rare thus financial support for research is limited. Likewise, the treatment of these diseases are usually dependent on a mixture of vitamins, a change of diet, and there is no universal treatment method as most are tailored to the individual. The disease is hard to diagnose due to changing diagnostic criteria and " overall lack of genotype-phenotype correlations".
Collectively, these treatments revolve around vitamin based therapies and cofactor based therapies like acyl Coenzyme A in mitochondria. Others focus on providing alternative energy source or bypassing biochemical blocks.
Current goals (2009) for these therapies are to increase ATP production and minimize free radical production which will improve overall mitochondrial health.
Ketogenic diet is recommended for mitochondrial disease patients as they have secondary fatty acid oxidation disorders. And is mainly used in treatment of pyruvate dehydrogenase deficiencyl
Some standard drugs that treat mitochondrial diseases are given in Table 2. Mitochondrial Medications and Supplements.
Mainly,
Coenzyme Q-10 ubiquinone in the form of the more absorbent ubiquinol (reduced CoQ) is found to be more absorbent and effective in treating the disease when used as a form of treatment. It is present in the electron transport chain where it transports electrons from Complex I and II from fatty acid beta oxidation to produce ATP. Thus using this as a supplement to the damaged or malfunctioning mitochondria to produce energy is a form of treatment.
Ribofavin- Essentially vitamin B2, is a precursor to riboflavin which is a key component of complex I and II in the electron transport chain and subsequent fatty acid oxidization in Kreb's cycle.
Also given are : Table 1. Drugs with reported mitochondrial toxicity
: Table 2. Mitochondrial Medications and Supplements
Link-http://www.fodsupport.org/documents/Modern-Approach-to-Treatment-of-Mito.pdf
Collectively, these treatments revolve around vitamin based therapies and cofactor based therapies like acyl Coenzyme A in mitochondria. Others focus on providing alternative energy source or bypassing biochemical blocks.
Current goals (2009) for these therapies are to increase ATP production and minimize free radical production which will improve overall mitochondrial health.
Ketogenic diet is recommended for mitochondrial disease patients as they have secondary fatty acid oxidation disorders. And is mainly used in treatment of pyruvate dehydrogenase deficiencyl
Some standard drugs that treat mitochondrial diseases are given in Table 2. Mitochondrial Medications and Supplements.
Mainly,
Coenzyme Q-10 ubiquinone in the form of the more absorbent ubiquinol (reduced CoQ) is found to be more absorbent and effective in treating the disease when used as a form of treatment. It is present in the electron transport chain where it transports electrons from Complex I and II from fatty acid beta oxidation to produce ATP. Thus using this as a supplement to the damaged or malfunctioning mitochondria to produce energy is a form of treatment.
Ribofavin- Essentially vitamin B2, is a precursor to riboflavin which is a key component of complex I and II in the electron transport chain and subsequent fatty acid oxidization in Kreb's cycle.
Also given are : Table 1. Drugs with reported mitochondrial toxicity
: Table 2. Mitochondrial Medications and Supplements
Link-http://www.fodsupport.org/documents/Modern-Approach-to-Treatment-of-Mito.pdf
RSS Feed